Open AccessSafety and efficacy of l ‐lysine monohydrochloride produced by fermentation with Corynebacterium glutamicum DSM 32932 for all animal species
Author(s) -
Bampidis Vasileios,
Azimonti Giovanna,
Lourdes Bastos Maria,
Christensen Henrik,
Dusemund Birgit,
Kos Durjava Mojca,
Kouba Maryline,
LópezAlonso Marta,
López Puente Secundino,
Marcon Francesca,
Mayo Baltasar,
Pechová Alena,
Petkova Mariana,
Ramos Fernando,
Sanz Yolanda,
Villa Roberto Edoardo,
Woutersen Ruud,
Cocconcelli Pier Sandro,
Glandorf Boet,
Herman Lieve,
Maradona Miguel Prieto,
Saarela Maria,
Anguita Montserrat,
Galobart Jaume,
Holczknecht Orsolya,
Manini Paola,
Pettenati Elisa,
Pizzo Fabiola,
TarrésCall Jordi
Publication year - 2020
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2020.6078
Subject(s) - corynebacterium glutamicum , lysine , rumen , animal feed , ruminant , fermentation , strain (injury) , food science , biology , biochemistry , feed additive , chemistry , microbiology and biotechnology , amino acid , agronomy , crop , gene , anatomy , broiler
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l ‐lysine monohydrochloride produced by fermentation with the genetically modified strain of Corynebacterium glutamicum DSM 32932. Neither the production strain nor its recombinant DNA were detected in the final product. The additive does not pose any safety concern associated with the genetic modification of the production strain. l ‐Lysine HCl produced by C. glutamicum DSM 32932 is considered safe for the target species, for the consumer and for the environment. l ‐Lysine HCl produced by C. glutamicum DSM 32932 is not toxic by inhalation; it is not irritant to skin and not a skin sensitiser. The additive is not corrosive to eyes but it should be considered as an eye irritant. In general, l ‐lysine HCl is considered as an efficacious source of the essential amino acid l ‐lysine for non‐ruminant animal species. For the supplemental l ‐lysine to be as efficacious in ruminants as in non‐ruminant species, it would require protection against degradation in the rumen.