Open AccessScientific Opinion of the Scientific Panel on Plant Protection Products and their Residues ( PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances)
Author(s) -
HernandezJerez Antonio F,
Adriaanse Paulien,
Aldrich Annette,
Berny Philippe,
Coja Tamara,
Duquesne Sabine,
Gimsing Anne Louise,
Marinovich Marina,
Millet Maurice,
Pelkonen Olavi,
Pieper Silvia,
Tiktak Aaldrik,
Topping Christopher J,
Tzoulaki Ioanna,
Widenfalk Anneli,
Wolterink Gerrit,
Benford Diane,
Aquilina Gabriele,
Bignami Margherita,
Bolognesi Claudia,
Crebelli Riccardo,
Guertler Rainer,
Marcon Francesca,
Nielsen Elsa,
Schlatter Josef Rudolf,
Vleminckx Christiane,
Maurici Daniela,
Parra Morte Juan Manuel
Publication year - 2020
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2020.6053
Subject(s) - genotoxicity , triazine , amine gas treating , metabolite , chemistry , 1,3,5 triazine , pharmacology , ames test , toxicology , biochemistry , biology , organic chemistry , toxicity , genetics , salmonella , bacteria
The Panel received a mandate from the European Commission to assess the genotoxic potential of triazine amine based on available information submitted by the applicants. Available information includes experimental genotoxicity data on triazine amine, Quantitative Structure–Activity Relationship ( QSAR ) analysis and read across with structurally similar compounds. Based on the overall weight of evidence, the Panel, in agreement with the cross‐cutting Working Group Genotoxicity, concluded that there is no concern for the potential of triazine amine to induce gene mutations and clastogenicity; however, the potential to induce aneugenicity was not adequately investigated. For a conclusion, an in vitro micronucleus assay performed with triazine amine would be needed.