Open AccessRisk assessment of chlorinated paraffins in feed and food
Author(s) -
Schrenk Dieter,
Bignami Marguerita,
Bodin Laurent,
Chipman James Kevin,
del Mazo Jesús,
GraslKraupp Bettina,
Hogstrand Christer,
Hoogenboom Laurentius Ron,
Leblanc JeanCharles,
Nebbia Carlo Stefano,
Ntzani Evangelia,
Petersen Annette,
Sand Salomon,
Schwerdtle Tanja,
Vleminckx Christiane,
Wallace Heather,
Brüschweiler Beat,
Leonards Pim,
Rose Martin,
Binaglia Marco,
Horváth Zsuzsanna,
Ramos Bordajandi Luisa,
Nielsen Elsa
Publication year - 2020
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2020.5991
Subject(s) - chlorinated paraffins , risk assessment , reference dose , toxicology , physiology , toxicity , fish <actinopterygii> , toxicokinetics , european commission , biology , environmental health , medicine , chemistry , european union , computer security , organic chemistry , computer science , business , economic policy , fishery
The European Commission asked EFSA for a scientific opinion on the risks for animal and human health related to the presence of chlorinated paraffins in feed and food. The data for experimental animals were reviewed and the CONTAM Panel identified the liver, kidney and thyroid as the target organs for the SCCP and MCCP mixtures tested in repeated dose toxicity studies. Decreased pup survival and subcutaneous haematoma/haemorrhage were also identified as critical effects for an MCCP mixture. For the LCCP mixtures tested, the liver was identified as the target organ. The Panel selected as reference points a BMDL 10 of 2.3 mg/kg bw per day for increased incidence of nephritis in male rats, and of 36 mg/kg bw per day for increased relative kidney weights in male and female rats for SCCP s and MCCP s, respectively. For LCCP s, a reference point relevant for humans could not be identified. Due to the limitations in the toxicokinetic and toxicological database, the Panel concluded that derivation of a health‐based guidance value was not appropriate. Only limited data on the occurrence of SCCP s and MCCP s in some fish species were submitted to EFSA . No data were submitted for LCCP s. Thus, a robust exposure assessment and consequently a complete risk characterisation could not be performed. A preliminary risk characterisation based only on the consumption of fish was performed, and the calculated margins of exposure suggested no health concern for this limited scenario. The Panel noted that dietary exposure will be higher due to the contribution of CP s from other foods. The Panel was not able to identify reference points for farm animals, horses and companion animals. No occurrence data for feed were submitted to EFSA . Therefore, no risk characterisation could be performed for any of these animal species.