Open AccessEstablishment of cumulative assessment groups of pesticides for their effects on the thyroid
Author(s) -
Crivellente Federica,
Hart Andy,
HernandezJerez Antonio F.,
Hougaard Bennekou Susanne,
Pedersen Ragnor,
Terron Andrea,
Wolterink Gerrit,
Mohimont Luc
Publication year - 2019
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2019.5801
Subject(s) - thyroid , risk assessment , pesticide , cumulative risk , medicine , hyperplasia , cumulative dose , endocrinology , biology , computer science , computer security , agronomy
Cumulative assessment groups of pesticides have been established for two specific effects on the thyroid: firstly hypothyroidism, and secondly parafollicular cell (C‐cell) hypertrophy, hyperplasia and neoplasia. Sources of uncertainties resulting from the methodological approach and from the limitations in available data and scientific knowledge have been identified and considered. This report supports the publication of a scientific report on cumulative risk assessment to pesticides affecting the thyroid, in which all uncertainties identified for either the exposure assessment or the establishment of the cumulative assessment groups are incorporated into a consolidated risk characterisation.