Open AccessEstablishment of cumulative assessment groups of pesticides for their effects on the nervous system
Author(s) -
Crivellente Federica,
Hart Andy,
HernandezJerez Antonio F,
Hougaard Bennekou Susanne,
Pedersen Ragnor,
Terron Andrea,
Wolterink Gerrit,
Mohimont Luc
Publication year - 2019
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2019.5800
Subject(s) - pesticide , acetylcholinesterase , risk assessment , cumulative risk , nervous system , quantitative assessment , central nervous system , cumulative dose , sensory system , autonomic nervous system , neuroscience , medicine , biology , toxicology , physiology , computer science , risk analysis (engineering) , ecology , enzyme , biochemistry , heart rate , computer security , blood pressure
Cumulative assessment groups of pesticides have been established for five effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, functional alterations of the motor, sensory and autonomic divisions, and histological neuropathological changes in neural tissue. Sources of uncertainties resulting from the methodological approach and from the limitations in available data and scientific knowledge have been identified and considered. This report supports the publication of a scientific report on cumulative risk assessment to pesticides affecting the nervous system, in which all uncertainties identified for either the exposure assessment or the establishment of the cumulative assessment groups are incorporated into a consolidated risk characterisation.