Open AccessSafety and efficacy of l ‐histidine monohydrochloride monohydrate produced by fermentation with Escherichia coli ( NITE BP ‐02526) for all animal species
Author(s) -
Bampidis Vasileios,
Azimonti Giovanna,
Bastos Maria de Lourdes,
Christensen Henrik,
Dusemund Birgit,
Kouba Maryline,
Kos Durjava Mojca,
LópezAlonso Marta,
López Puente Secundino,
Marcon Francesca,
Mayo Baltasar,
Pechová Alena,
Petkova Mariana,
Ramos Fernando,
Sanz Yolanda,
Villa Roberto Edoardo,
Woutersen Ruud,
Glandorf Boet,
Herman Lieve,
Maradona Prieto Miguel,
Saarela Maria,
Tosti Luca,
Anguita Montserrat,
Galobart Jaume,
Holczknecht Orsolya,
Manini Paola,
TarresCall Jordi,
Pettenati Elisa,
Pizzo Fabiola
Publication year - 2019
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2019.5785
Subject(s) - histidine , escherichia coli , fermentation , animal feed , feed additive , food science , histidine decarboxylase , chemistry , biology , biochemistry , microbiology and biotechnology , amino acid , broiler , gene
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed ( FEEDAP ) was asked to deliver a scientific opinion on l ‐histidine monohydrochloride monohydrate produced by fermentation with Escherichia coli ( NITE BP ‐02526) when used as a nutritional additive or as a feed flavouring compound in feed and water for drinking for all animal species. The product under assessment is l ‐histidine HC l H 2 O produced by fermentation with a genetically modified strain of E. coli ( NITE BP ‐02526). The production strain and its recombinant DNA were not detected in the final products. l ‐Histidine HC l H 2 O does not give rise to any safety concern to the production strain. The use of l ‐histidine HC l H 2 O is safe for the target species when used to supplement the diet in appropriate amounts. It is safe at the proposed use level of 25 mg/kg when used as a flavouring compound for all animal species. The use of l ‐histidine HC l H 2 O in animal nutrition raises no safety concerns for consumers of animal products. The additive is not irritating to the skin or eyes and is not a skin sensitiser. There is a risk for persons handling the additive from the exposure to endotoxins by inhalation. The use of l ‐histidine as a feed additive does not represent a risk to the environment. The additive l ‐histidine HC l H 2 O is regarded as an effective source of the amino acid l ‐histidine when used as a nutritional additive. For the supplemental l ‐histidine to be as efficacious in ruminants as in non‐ruminant species, it requires protection against degradation in the rumen. It is also considered efficacious as a feed flavouring compound under the proposed conditions of use.