Open AccessSafety and efficacy of l ‐histidine monohydrochloride monohydrate produced using Corynebacterium glutamicum KCCM 80172 for all animal species
Author(s) -
Bampidis Vasileios,
Azimonti Giovanna,
Bastos Maria de Lourdes,
Christensen Henrik,
Dusemund Birgit,
Kouba Maryline,
Kos Durjava Mojca,
LópezAlonso Marta,
López Puente Secundino,
Marcon Francesca,
Mayo Baltasar,
Pechová Alena,
Petkova Mariana,
Sanz Yolanda,
Villa Roberto Edoardo,
Woutersen Ruud,
Costa Lucio,
Cubadda Francesco,
Dierick Noël,
Flachowsky Gerhard,
Glandorf Boet,
Herman Lieve,
Mantovani Alberto,
Saarela Maria,
Svensson Kettil,
Tosti Luca,
Wallace Robert John,
Anguita Montserrat,
TarrésCall Jordi,
Ramos Fernando
Publication year - 2019
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2019.5783
Subject(s) - corynebacterium glutamicum , histidine , fermentation , food science , feed additive , chemistry , animal feed , biochemistry , microbiology and biotechnology , biology , amino acid , broiler , gene
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed ( FEEDAP ) was asked to deliver a scientific opinion on l ‐histidine monohydrochloride ( HC l) monohydrate produced by fermentation using Corynebacterium glutamicum KCCM 80172 when used as a nutritional additive in feed and water for drinking for all animal species. The production strain is genetically modified. The production strain and its recombinant DNA were not detected in the final product. l ‐Histidine HC l monohydrate manufactured by fermentation using C . glutamicum KCCM 80172 does not give rise to any safety concern regarding the genetic modification. The use of l ‐histidine HC l monohydrate produced by fermentation using C . glutamicum KCCM 80172 is safe for the target species when used as a nutritional additive to supplement the diet in appropriate amounts to cover the requirements, depending on the species, the physiological state of the animal, the performance level, the environmental conditions, the background amino acid composition of the unsupplemented diet and the status of some essential trace elements such as copper and zinc. l ‐Histidine HC l monohydrate produced using C . glutamicum KCCM 80172 supplemented at levels appropriate for the requirements of the target species is considered safe for the consumer. l ‐Histidine HC l monohydrate produced using C . glutamicum KCCM 80172 is not irritant to skin, is a mildly irritant to eyes, and it is not a skin sensitiser. The additive does not pose a risk to users by inhalation. The use of l ‐histidine HC l monohydrate produced by C. glutamicum KCCM 80172 in animal nutrition is not expected to represent a risk to the environment. l ‐Histidine HC l monohydrate is considered an efficacious source of the essential amino acid l ‐histidine for non‐ruminant animal species. For the supplemental l ‐histidine to be as efficacious in ruminants as in non‐ruminant species, it would require protection against degradation in the rumen.