Open AccessSafety of phenylcapsaicin as a novel food pursuant to Regulation ( EU ) 2015/2283
Author(s) -
Turck Dominique,
Castenmiller Jacqueline,
De Henauw Stefaan,
HirschErnst Karen Ildico,
Kearney John,
Maciuk Alexandre,
Mangelsdorf Inge,
McArdle Harry J,
Naska Androniki,
Pelaez Carmen,
Pentieva Kristina,
Siani Alfonso,
Thies Frank,
Tsabouri Sophia,
Vinceti Marco,
Cubadda Francesco,
Engel Karl Heinz,
Frenzel Thomas,
Hein Marina,
Marchelli Rosangela,
NeuhäuserBerthold Monika,
Pöting Annette,
Poulsen Morten,
Sanz Yolanda,
Schlatter Josef Rudolf,
Loveren Henk,
Amundsen Mathias,
Knutsen Helle Katrine
Publication year - 2019
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2019.5718
Subject(s) - european commission , food safety , european union , medicine , population , food intake , zoology , body weight , food science , toxicology , environmental health , biology , business , economic policy
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens ( NDA ) was asked to deliver an opinion on phenylcapsaicin as a novel food ( NF ) pursuant to Regulation ( EU ) 2015/2283. Phenylcapsaicin is a chemically synthesised analogue of capsaicin intended to be marketed in food supplements and in foods for special medical purposes to the general population above the age of 11 years old at a maximum level of 2.5 mg/day. The highest intake of the NF is 2.5 mg/day which corresponds to 36 μg/kg body weight (bw) per day for adults, and 58 μg/kg bw per day for adolescents (10–14 years). The Panel considers that there is no concern with respect to genotoxicity of the NF . The reference point derived based on a 13‐week rat study was the lowest of the model averaged BMDL 20 values of 37.2 mg/kg bw per day in females for increased plasma alanine aminotransferase ( ALAT ) levels. The Panel concludes that the NF , phenylcapsaicin, is safe under the proposed uses and use levels.