Open AccessScientific Opinion on the setting of health‐based reference values for metabolites of the active substance terbuthylazine
Author(s) -
HernandezJerez Antonio F,
Adriaanse Paulien,
Aldrich Annette Patrizia,
Berny Philippe,
Duquesne Sabine,
Gimsing Anne Louise,
Millet Maurice,
Pelkonen Olavi,
Pieper Silvia,
Tiktak Aaldrik,
Topping Christopher John,
Tzoulaki Ioanna,
Widenfalk Anneli,
Wolterink Gerrit,
Kuhl Thomas,
Friel Anja,
Istace Frederique,
Kardassi Dimitra,
Lythgo Christopher,
Serafimova Rositsa,
Coja Tamara
Publication year - 2019
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2019.5712
Subject(s) - terbuthylazine , environmental science , toxicology , environmental chemistry , environmental health , medicine , pesticide , chemistry , biology , atrazine , agronomy
The EFSA Panel on Plant Protection Products and their Residues was requested to establish health‐based reference values for groundwater metabolites ( LM 2, LM 3, LM 4, LM 5 and LM 6) of the active substance terbuthylazine based on the available evidence, unless the evidence was considered insufficient to do so. The request was accepted under the explicit circumstance that the reassessment would be made according to a different methodology than the routine methodology currently applied for the assessment of metabolites in groundwater. While for metabolites LM 2, LM 4 and LM 5, it was concluded that the reference values for terbuthylazine are applicable, substance‐specific reference values could not be derived for metabolites LM 3 and LM 6. The applied threshold of toxicological concern ( TTC ) approach has shown that metabolites LM 3 and LM 6 are of potential concern for consumer health, since at least one representative groundwater leaching scenario results in exposure above the relevant threshold. Moreover, other sources of exposure to LM 3 and LM 6 could not be excluded with certainty. It is therefore recommended to address the specific toxicities of metabolites LM 3 and LM 6.