Open AccessSafety and efficacy of l ‐lysine monohydrochloride and concentrated liquid l ‐lysine (base) produced by fermentation using Corynebacterium glutamicum strain KCCM 10227 for all animal species
Author(s) -
Bampidis Vasileios,
Azimonti Giovanna,
Bastos Maria,
Christensen Henrik,
Dusemund Birgit,
Kouba Maryline,
Kos Durjava Mojca,
LópezAlonso Marta,
López Puente Secundino,
Marcon Francesca,
Mayo Baltasar,
Pechová Alena,
Petkova Mariana,
Sanz Yolanda,
Villa Roberto Edoardo,
Woutersen Ruud,
Costa Lucio,
Cubadda Francesco,
Dierick Noël,
Flachowsky Gerhard,
Mantovani Alberto,
Wallace Robert John,
TarresCall Jordi,
Ramos Fernando
Publication year - 2019
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2019.5697
Subject(s) - corynebacterium glutamicum , lysine , food science , chemistry , fermentation , animal feed , rumen , biochemistry , biology , amino acid , gene
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed ( FEEDAP ) was asked to deliver a scientific opinion on l ‐lysine monohydrochloride and concentrated liquid l ‐lysine (base) produced using Corynebacterium glutamicum KCCM 10227 when used as nutritional additives in feed and water for drinking for all animal species. The active substance is l ‐lysine. l ‐lysine HCl and concentrated liquid l ‐lysine (base) produced by the strain C. glutamicum KCCM 10227 do not represent a risk for the target species, the consumer and the environment. l ‐lysine HCl produced by C. glutamicum KCCM 10227 is hazardous by inhalation, it is not irritant to skin but mildly irritant to eyes and it is not a skin sensitiser. Concentrated liquid l ‐lysine (base) produced by C. glutamicum KCCM 10227 is hazardous by inhalation, not irritant to skin and eyes and it is not a skin sensitiser. l ‐lysine HC l and concentrated liquid l ‐lysine (base) are considered as efficacious sources of the essential amino acid l ‐lysine for non‐ruminant animal species. For the supplemental l ‐lysine to be as efficacious in ruminants as in non‐ruminant species, it would require protection against degradation in the rumen.