Open AccessSafety and efficacy of l ‐threonine produced by fermentation with Corynebacterium glutamicum KCCM 80117 for all animal species
Author(s) -
Bampidis Vasileios,
Azimonti Giovanna,
Bastos Maria de Lourdes,
Christensen Henrik,
Dusemund Birgit,
Kouba Maryline,
Kos Durjava Mojca,
LópezAlonso Marta,
López Puente Secundino,
Marcon Francesca,
Mayo Baltasar,
Pechová Alena,
Petkova Mariana,
Sanz Yolanda,
Villa Roberto Edoardo,
Woutersen Ruud,
Costa Lucio,
Dierick Noël,
Flachowsky Gerhard,
Mantovani Alberto,
Wallace Robert John,
TarrésCall Jordi,
Ramos Fernando
Publication year - 2019
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2019.5602
Subject(s) - corynebacterium glutamicum , threonine , animal feed , fermentation , food science , rumen , biochemistry , biology , microbiology and biotechnology , chemistry , enzyme , serine , gene
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed ( FEEDAP ) was asked to deliver a scientific opinion on l ‐threonine produced by fermentation with Corynebacterium glutamicum KCCM 80117 when used as a nutritional additive in feed and water for drinking for all animal species and categories. The product under assessment is l ‐threonine produced by fermentation with a strain of C. glutamicum (KCCM 80117). l ‐Threonine produced by C. glutamicum KCCM 80117 is considered safe for the target species when supplemented in appropriate amounts to the diet. The FEEDAP Panel has concerns on the safety of the simultaneous oral administration of l ‐threonine via water for drinking and feed. l ‐Threonine produced using C. glutamicum KCCM 80117 is safe for the consumer. The additive is not a skin or eye irritant and is not a skin sensitiser. Although the workers can be exposed by inhalation, the results of an acute inhalation study showed that risk of adverse effects by inhalation is low. l ‐Threonine produced using C. glutamicum KCCM 80117 is safe for the environment. The product under assessment is considered an efficacious source of the amino acid l ‐threonine for all animal species. For l ‐threonine to be as efficacious in ruminants as in non‐ruminant species, it requires protection against degradation in the rumen.