Open AccessSafety and efficacy of l ‐tryptophan produced by fermentation with Escherichia coli CGMCC 7.248 for all animal species
Author(s) -
Bampidis Vasileios,
Azimonti Giovanna,
Bastos Maria de Lourdes,
Christensen Henrik,
Dusemund Birgit,
Kouba Maryline,
Kos Durjava Mojca,
LópezAlonso Marta,
López Puente Secundino,
Marcon Francesca,
Mayo Baltasar,
Pechová Alena,
Petkova Mariana,
Sanz Yolanda,
Villa Roberto Edoardo,
Woutersen Ruud,
Costa Lucio,
Dierick Noël,
Flachowsky Gerhard,
Glandorf Boet,
Herman Lieve,
Mantovani Alberto,
Saarela Maria,
Wallace Robert John,
Anguita Montserrat,
TarrésCall Jordi,
Ramos Fernando
Publication year - 2019
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2019.5601
Subject(s) - tryptophan , ruminant , escherichia coli , fermentation , food science , animal feed , feed additive , microbiology and biotechnology , strain (injury) , chemistry , biology , biochemistry , amino acid , agronomy , crop , anatomy , broiler , gene
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed ( FEEDAP ) was asked to deliver a scientific opinion on l ‐tryptophan produced by fermentation with a genetically modified strain of Escherichia coli CGMCC 7.248 when used as a nutritional additive in feed and water for drinking for all animal species and categories. The production strain E. coli CGMCC 7.248 and its recombinant DNA were not detected in the final product. The product l ‐tryptophan, manufactured by fermentation with E. coli CGMCC 7.248, does not give rise to any safety concern with regard to the genetic modification of the production strain. l ‐Tryptophan produced by E. coli CGMCC 7.248 is safe for non‐ruminant target species. The use of unprotected l ‐tryptophan in ruminant feed should be avoided. l ‐Tryptophan produced by fermentation by E. coli CGMCC 7.248 is safe for the consumer. The level of endotoxins present in the product and its dusting potential indicate an inhalation risk for the user. l ‐Tryptophan produced by E. coli CGMCC 7.248 is not a skin or eye irritant but it is a dermal sensitiser. The use of l ‐tryptophan produced by E. coli CGMCC 7.248 in animal nutrition does not pose a risk to the environment. The product under assessment is regarded as an effective source of the amino acid l ‐tryptophan for all non‐ruminant species. For the supplemental l ‐tryptophan to be as efficacious in ruminants as in non‐ruminant species, it requires protection against degradation in the rumen.