Open AccessAssessment of genetically modified maize MON 89034 × 1507 × MON 88017 × 59122 × DAS ‐40278‐9 and subcombinations independently of their origin for food and feed uses, import and processing under Regulation ( EC ) No 1829/2003 (application EFSA ‐ GMO ‐ NL ‐2013‐113)
Author(s) -
Naegeli Hanspeter,
Bresson JeanLouis,
Dalmay Tamas,
Dewhurst Ian Crawford,
Epstein Michelle M,
Firbank Leslie George,
Guerche Philippe,
Hejatko Jan,
Moreno Francisco Javier,
Mullins Ewen,
Nogué Fabien,
Rostoks Nils,
Sánchez Serrano Jose Juan,
Savoini Giovanni,
Veromann Eve,
Veronesi Fabio,
Ardizzone Michele,
Fernandez Dumont Antonio,
Gennaro Andrea,
Gómez Ruiz Jose Ángel,
Lanzoni Anna,
Neri Franco Maria,
Papadopoulou Nikoletta,
Ramon Matthew
Publication year - 2019
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2019.5521
Subject(s) - genetically modified maize , zea mays , environmental safety , microbiology and biotechnology , event (particle physics) , biology , toxicology , genetically modified crops , agricultural science , agronomy , transgene , medicine , environmental health , biochemistry , human health , physics , quantum mechanics , gene
Maize MON 89034 × 1507 × MON 88017 × 59122 × DAS ‐40278‐9 (five‐event stack maize) was produced by conventional crossing to combine five single events: MON 89034, 1507, MON 88017, 59122 and DAS ‐40278‐9. The GMO Panel previously assessed the 5 single maize events and 11 of their subcombinations and did not identify safety concerns. No new data on the single maize events or their 11 subcombinations that could modify the original conclusions on their safety were identified. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicates that the combination of the single maize events and of the newly expressed proteins in the five‐event stack maize does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that the five‐event stack maize, as described in this application, is as safe as and nutritionally equivalent to its non‐ GM comparator and the non‐ GM reference varieties tested. In the case of accidental release of the five‐event stack maize into the environment, this would not raise environmental safety concerns. The GMO Panel assessed the likelihood of interactions among the single events in the 14 maize subcombinations for which no experimental data were provided, and concludes that they are expected to be as safe as and nutritionally equivalent to the single events, the previously assessed subcombinations and the five‐event stack maize. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of the five‐event stack maize. No post‐market monitoring of food/feed is considered necessary. The GMO Panel concludes that the five‐event stack maize and its subcombinations are as safe as its non‐ GM comparator and the tested non‐ GM reference varieties with respect to potential effects on human and animal health and the environment.