Open AccessScientific Opinion on Flavouring Group Evaluation 200, Revision 1 ( FGE .200 Rev.1): 74 α,β‐unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.1 of FGE .19
Author(s) -
Younes Maged,
Aquilina Gabriele,
Castle Laurence,
Engel KarlHeinz,
Fowler Paul,
Frutos Fernandez Maria Jose,
Fürst Peter,
GundertRemy Ursula,
Husøy Trine,
Mennes Wim,
Moldeus Peter,
Oskarsson Agneta,
Rainieri Sandra,
Shah Romina,
WaalkensBerendsen Ine,
Wölfle Detlef,
Binderup MonaLise,
Bolognesi Claudia,
Marcon Francesca,
Marzin Daniel,
Mosesso Pasquale,
Carfì Maria,
Vianello Giorgia,
Gürtler Rainer
Publication year - 2018
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2018.5422
Subject(s) - genotoxicity , chemistry , in vivo , food contact materials , toxicology , food science , stereochemistry , pharmacology , organic chemistry , food packaging , toxicity , medicine , biology , microbiology and biotechnology
Abstract The Panel on Food Additives and Flavourings of the European Food Safety Authority was requested to evaluate the genotoxic potential of 74 flavouring substances from subgroup 1.1.1 of FGE .19 in the Flavouring Group Evaluation 200 Revision 1 ( FGE .200 Rev1). In FGE .200, genotoxicity studies were provided for one representative substance, namely hex‐2( trans )‐enal [ FL ‐no: 05.073], and for other two substances in the same subgroup, namely 2‐dodecenal [ FL ‐no: 05.037] and 2‐nonenal [ FL ‐no: 05.171]. The Panel concluded that the concern still remains with respect to genotoxicity for the substances of this subgroup and requested an in vivo Comet assay performed in duodenum and liver for hex‐2( trans )‐enal [ FL ‐no: 05.073]. For the two other representative substances of subgroup 1.1.1 (nona‐2( trans ),6( cis )‐dienal [ FL ‐no: 05.058] and oct‐2‐enal [ FL ‐no: 05.060]), the Panel requested a combined in vivo Comet assay and micronucleus assay. These data have been provided and are evaluated in the present opinion FGE .200 Rev1. Industry submitted genotoxicity studies on trans ‐2‐octenal [ FL ‐no: 05.190], instead of oct‐2‐enal [ FL ‐no: 05.060]. Based on the available data, the Panel concluded that the concern for genotoxicity can be ruled out for hex‐2( trans )‐enal [ FL ‐no: 05.073], trans ‐2‐octenal [ FL ‐no: 05.190] and nona‐2( trans ),6( cis )‐dienal [ FL ‐no: 05.058], therefore all the 74 substances [ FL ‐no: 02.020, 02.049, 02.050, 02.090, 02.112, 02.137, 02.156, 02.192, 02.210, 02.231, 05.037, 05.058, 05.060, 05.070, 05.072, 05.073, 05.076, 05.078, 05.102, 05.109, 05.111, 05.114, 05.120, 05.144, 05.150, 05.171, 05.172, 05.179, 05.184, 05.189, 05.190, 05.191, 05.195, 06.025, 06.031, 06.072, 09.054, 09.097, 09.109, 09.119, 09.146, 09.233, 09.244, 09.247, 09.276, 09.277, 09.303, 09.312, 09.385, 09.394, 09.395, 09.396, 09.397, 09.398, 09.399, 09.400, 09.410, 09.411, 09.469, 09.482, 09.489, 09.492, 09.493, 09.498, 09.678, 09.701, 09.719, 09.741, 09.790, 09.841, 09.866, 09.947, 09.948, 13.004] can be evaluated through the Procedure for flavouring substances.