z-logo
open-access-imgOpen Access
Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed
Author(s) -
Knutsen Helle Katrine,
Alexander Jan,
Barregård Lars,
Bignami Margherita,
Brüschweiler Beat,
Ceccatelli Sandra,
Cottrill Bruce,
Dinovi Michael,
GraslKraupp Bettina,
Hogstrand Christer,
Hoogenboom Laurentius Ron,
Nebbia Carlo Stefano,
Oswald Isabelle P,
Petersen Annette,
Rose Martin,
Roudot AlainClaude,
Schwerdtle Tanja,
Vleminckx Christiane,
Vollmer Günter,
Wallace Heather,
De Saeger Sarah,
Eriksen Gunnar Sundstøl,
Farmer Peter,
Fremy JeanMarc,
Gong Yun Yun,
Meyer Karsten,
ParentMassin Dominique,
van Egmond Hans,
Altieri Andrea,
Colombo Paolo,
Horváth Zsuzsanna,
Levorato Sara,
Edler Lutz
Publication year - 2018
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2018.5367
Subject(s) - human health , library science , medicine , environmental health , computer science
4,15‐Diacetoxyscirpenol ( DAS ) is a mycotoxin primarily produced by Fusarium fungi and occurring predominantly in cereal grains. As requested by the European Commission, the EFSA Panel on Contaminants in the Food Chain ( CONTAM ) assessed the risk of DAS to human and animal health related to its presence in food and feed. Very limited information was available on toxicity and on toxicokinetics in experimental and farm animals. Due to the limitations in the available data set, human acute and chronic health‐based guidance values ( HBGV ) were established based on data obtained in clinical trials of DAS as an anticancer agent (anguidine) after intravenous administration to cancer patients. The CONTAM Panel considered these data as informative for the hazard characterisation of  DAS after oral exposure. The main adverse effects after acute and repeated exposure were emesis, with a no‐observed‐adverse‐effect level ( NOAEL ) of 32 μg DAS /kg body weight (bw), and haematotoxicity, with a NOAEL of 65 μg DAS /kg bw, respectively. An acute reference dose ( AR fD) of 3.2 μg DAS /kg bw and a tolerable daily intake ( TDI ) of 0.65 μg DAS /kg bw were established. Based on over 15,000 occurrence data, the highest acute and chronic dietary exposures were estimated to be 0.8 and 0.49 μg DAS /kg bw per day, respectively, and were not of health concern for humans. The limited information for poultry, pigs and dogs indicated a low risk for these animals at the estimated DAS exposure levels under current feeding practices, with the possible exception of fattening chicken. Assuming similar or lower sensitivity than for poultry, the risk was considered overall low for other farm and companion animal species for which no toxicity data were available. In consideration of the similarities of several trichothecenes and the likelihood of co‐exposure via food and feed, it could be appropriate to perform a cumulative risk assessment for this group of substances.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here