Open AccessAssessment of genetically modified maize 4114 for food and feed uses, under Regulation ( EC ) No 1829/2003 (application EFSA ‐ GMO ‐ NL ‐2014‐123)
Author(s) -
Naegeli Hanspeter,
Birch Andrew Nicholas,
Casacuberta Josep,
De Schrijver Adinda,
Gralak Mikołaj Antoni,
Guerche Philippe,
Jones Huw,
Manachini Barbara,
Messéan Antoine,
Nielsen Elsa Ebbesen,
Nogué Fabien,
Robaglia Christophe,
Rostoks Nils,
Sweet Jeremy,
Tebbe Christoph,
Visioli Francesco,
Wal JeanMichel,
Àlvarez Fernando,
Ardizzone Michele,
Paraskevopoulos Konstantinos,
Broll Hermann,
Devos Yann,
Fernandez Dumont Antonio,
Gómez Ruiz Jose Ángel,
Lanzoni Anna,
Neri Franco Maria,
Olaru Irina,
Papadopoulou Nikoletta
Publication year - 2018
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2018.5280
Subject(s) - bacillus thuringiensis , genetically modified organism , microbiology and biotechnology , genetically modified maize , genetically modified crops , context (archaeology) , biology , transgene , paleontology , biochemistry , genetics , bacteria , gene
Maize 4114 was developed through Agrobacterium tumefaciens ‐mediated transformation to provide protection against certain lepidopteran and coleopteran pests by expression of the Cry1F, Cry34Ab1 and Cry35Ab1 proteins derived from Bacillus thuringiensis , and tolerance to the herbicidal active ingredient glufosinate‐ammonium by expression of the PAT protein derived from Streptomyces viridochromogenes . The molecular characterisation data did not identify issues requiring assessment for food/feed safety. None of the compositional, agronomic and phenotypic differences identified between maize 4114 and the non‐genetically modified ( GM ) comparator(s) required further assessment. There were no concerns regarding the potential toxicity and allergenicity of the newly expressed proteins Cry1F, Cry34Ab1, Cry35Ab1 and PAT , and no evidence that the genetic modification might significantly change the overall allergenicity of maize 4114. The nutritional value of food/feed derived from maize 4114 is not expected to differ from that derived from non‐ GM maize varieties and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of viable maize 4114 grains into the environment, maize 4114 would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of maize 4114. The genetically modified organism ( GMO ) Panel concludes that maize 4114 is as safe as the non‐ GM comparator(s) and non‐ GM reference varieties with respect to potential effects on human and animal health and the environment in the context of the scope of this application.