Open AccessSafety and efficacy of hydroxy analogue of methionine and its calcium salt ( ADRY + ® ) for all animal species
Author(s) -
Rychen Guido,
Aquilina Gabriele,
Azimonti Giovanna,
Bampidis Vasileios,
Lourdes Bastos Maria,
Bories Georges,
Chesson Andrew,
Cocconcelli Pier Sandro,
Flachowsky Gerhard,
Gropp Jürgen,
Kolar Boris,
Kouba Maryline,
LópezAlonso Marta,
López Puente Secundino,
Mantovani Alberto,
Mayo Baltasar,
Ramos Fernando,
Saarela Maria,
Villa Roberto Edoardo,
Wester Pieter,
Costa Lucio,
Dierick Noël,
Leng Lubomir,
TarrésCall Jordi,
Wallace Robert John
Publication year - 2018
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2018.5198
Subject(s) - methionine , animal feed , chemistry , rumen , food science , ruminant , toxicity , zoology , biochemistry , biology , amino acid , organic chemistry , agronomy , fermentation , crop
The European Commission asked EFSA Panel on Additives and Products or Substances used in Animal Feed ( FEEDAP ) to deliver a scientific opinion on the safety and efficacy of ADRY + ® . ADRY + ® consists of hydroxy analogue of methionine ( HMTB a) and its calcium salt ( HMTB a‐Ca), both precursors of l ‐methionine. HMTB a and HMTB a‐Ca are currently authorised for use as a nutritional additives, under the functional group ‘amino acids, their salts and analogues’. ADRY + ® is produced by chemical synthesis and it is intended to be used in feed for all animal species and categories. The FEEDAP Panel concluded that ADRY + ® is safe for the target animals. The use of the additive in animal nutrition is not expected to result in an accumulation of HMTB a or its metabolites in edible tissues and animal products. Therefore, its use does not raise safety concerns for the consumer. ADRY + ® is irritant to eyes and not irritant to the skin. The FEEDAP Panel cannot conclude on the skin sensitisation potential of this additive. The exposure of the users to the additive by inhalation is expected to be low. The use of this product as a feed additive does not represent a risk to the environment. ADRY + ® is an effective source of methionine for protein synthesis in non‐ruminant animals and fish, although HMTB a may show a lower bioefficacy than dl ‐methionine. In ruminants, HMTB a is more slowly degraded in the rumen than dl ‐methionine.