Open AccessSafety and efficacy of l ‐threonine produced by fermentation with Escherichia coli CGMCC 11473 for all animal species
Author(s) -
Rychen Guido,
Aquilina Gabriele,
Azimonti Giovanna,
Bampidis Vasileios,
Bastos Maria de Lourdes,
Bories Georges,
Chesson Andrew,
Cocconcelli Pier Sandro,
Flachowsky Gerhard,
Gropp Jürgen,
Kolar Boris,
Kouba Maryline,
LópezAlonso Marta,
López Puente Secundino,
Mantovani Alberto,
Mayo Baltasar,
Ramos Fernando,
Saarela Maria,
Villa Roberto Edoardo,
Wester Pieter,
Costa Lucio,
Dierick Noël,
Leng Lubomir,
Glandorf Boet,
Herman Lieve,
Kärenlampi Sirpa,
Aguilera Jaime,
TarrésCall Jordi,
Wallace Robert John
Publication year - 2017
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2017.4939
Subject(s) - escherichia coli , threonine , animal feed , feed additive , rumen , genetically modified organism , biology , fermentation , food science , microbiology and biotechnology , biochemistry , enzyme , serine , gene , broiler
Abstract The product subject of this assessment is l ‐threonine produced by fermentation with a genetically modified strain of Escherichia coli ( CGMCC 11473). It is intended to be used in feed and water for drinking for all animal species and categories. It was not possible to characterise the genetic modification with the information provided. Uncertainty remained on the possible presence of cells from the production strain and their recombinant DNA in the product. Therefore, the EFSA Panel on Additives and Products or Substances used in Animal Feed ( FEEDAP ) could not conclude on the safety of the product l ‐threonine, produced by fermentation with Escherichia coli CGMCC 11473 for the target species, consumers and the environment. The FEEDAP Panel has concerns on the safety of the simultaneous oral administration of threonine containing additives via water for drinking and feed. In the absence of data, the FEEDAP Panel cannot conclude on the potential of the additive to be an irritant for skin and eyes or to be a skin sensitiser. There is a risk from the exposure by inhalation to endotoxins for persons handling the additive. The product under assessment is considered an efficacious source of the amino acid l ‐threonine for all animal species. For l ‐threonine to be as efficacious in ruminants as in non‐ruminant species, it requires protection against degradation in the rumen.