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Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed
Author(s) -
Knutsen Helle Katrine,
Alexander Jan,
Barregård Lars,
Bignami Margherita,
Brüschweiler Beat,
Ceccatelli Sandra,
Cottrill Bruce,
Dinovi Michael,
GraslKraupp Bettina,
Hogstrand Christer,
Hoogenboom Laurentius Ron,
Nebbia Carlo Stefano,
Oswald Isabelle P,
Petersen Annette,
Rose Martin,
Roudot AlainClaude,
Schwerdtle Tanja,
Vleminckx Christiane,
Vollmer Günter,
Wallace Heather,
De Saeger Sarah,
Eriksen Gunnar Sundstøl,
Farmer Peter,
Fremy JeanMarc,
Gong Yun Yun,
Meyer Karsten,
Naegeli Hanspeter,
ParentMassin Dominique,
Rietjens Ivonne,
van Egmond Hans,
Altieri Andrea,
Eskola Mari,
Gergelova Petra,
Ramos Bordajandi Luisa,
Benkova Bistra,
Dörr Barbara,
Gkrillas Athanasios,
Gustavsson Nicklas,
van Manen Mathijs,
Edler Lutz
Publication year - 2017
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2017.4718
Subject(s) - mycotoxin , tolerable daily intake , animal feed , fusarium , vomitoxin , food science , human health , forage , zoology , food contaminant , toxicology , biology , chemistry , body weight , zearalenone , medicine , agronomy , environmental health , botany , endocrinology
Deoxynivalenol ( DON ) is a mycotoxin primarily produced by Fusarium fungi, occurring predominantly in cereal grains. Following the request of the European Commission, the CONTAM Panel assessed the risk to animal and human health related to DON , 3‐acetyl‐ DON (3‐Ac‐ DON ), 15‐acetyl‐ DON (15‐Ac‐ DON ) and DON ‐3‐glucoside in food and feed. A total of 27,537, 13,892, 7,270 and 2,266 analytical data for DON , 3‐Ac‐ DON , 15‐Ac‐ DON and DON ‐3‐glucoside, respectively, in food, feed and unprocessed grains collected from 2007 to 2014 were used. For human exposure, grains and grain‐based products were main sources, whereas in farm and companion animals, cereal grains, cereal by‐products and forage maize contributed most. DON is rapidly absorbed, distributed, and excreted. Since 3‐Ac‐ DON and 15‐Ac‐ DON are largely deacetylated and DON ‐3‐glucoside cleaved in the intestines the same toxic effects as DON can be expected. The TDI of 1 μg/kg bw per day, that was established for DON based on reduced body weight gain in mice, was therefore used as a group‐ TDI for the sum of DON , 3‐Ac‐ DON , 15‐Ac‐ DON and DON ‐3‐glucoside. In order to assess acute human health risk, epidemiological data from mycotoxicoses were assessed and a group‐ AR fD of 8 μg/kg bw per eating occasion was calculated. Estimates of acute dietary exposures were below this dose and did not raise a health concern in humans. The estimated mean chronic dietary exposure was above the group‐ TDI in infants, toddlers and other children, and at high exposure also in adolescents and adults, indicating a potential health concern. Based on estimated mean dietary concentrations in ruminants, poultry, rabbits, dogs and cats, most farmed fish species and horses, adverse effects are not expected. At the high dietary concentrations, there is a potential risk for chronic adverse effects in pigs and fish and for acute adverse effects in cats and farmed mink.

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