Open AccessRisk assessment of new sequencing information on GM maize event DAS ‐59122‐7
Author(s) -
Naegeli Hanspeter,
Birch Andrew Nicholas,
Casacuberta Josep,
De Schrijver Adinda,
Gralak Mikolaj Antoni,
Guerche Philippe,
Jones Huw,
Manachini Barbara,
Messéan Antoine,
Nielsen Elsa Ebbesen,
Nogué Fabien,
Robaglia Christophe,
Rostoks Nils,
Sweet Jeremy,
Tebbe Christoph,
Visioli Francesco,
Wal JeanMichel,
Paraskevopoulos Konstantinos
Publication year - 2016
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2016.4639
Subject(s) - european commission , microbiology and biotechnology , biology , event (particle physics) , risk assessment , dna sequencing , computational biology , genetics , computer science , european union , gene , business , physics , computer security , quantum mechanics , economic policy
Abstract The EFSA Panel on Genetically Modified Organisms ( GMO Panel) has previously assessed genetically modified ( GM ) maize DAS ‐59122‐7 as a single event as well as part of several stacked events. These maize events were found to be as safe as their conventional counterparts and other appropriate comparators with respect to potential effects on human and animal health, and the environment. On 26 July 2016, the European Commission received from Pioneer new nucleic acid sequencing data on maize event DAS ‐59122‐7 and updated bioinformatic analyses using the new sequencing data. The European Commission tasked EFSA to analyse these data and to indicate whether the previous conclusions of the GMO Panel on the previously assessed GM maize events remain valid. The GMO Panel used the appropriate principles described in its guidelines for the risk assessment of GM plants to analyse the received data. The new sequencing data indicated three base pair (bp) differences compared to the sequencing data originally provided; two located in a non‐coding region of the insert and one located in the 5′ genomic flanking region. These base pairs reported as differences in the new nucleic acid sequencing data on maize event DAS ‐59122‐7 had already been present in the original plant material used for the risk assessment. Thus, with the exception of bioinformatics analyses, the studies performed for the risk assessment remain valid. The new sequencing data and the bioinformatic analyses performed on the new sequence did not give rise to safety issues. Therefore, the GMO Panel concludes that the original risk assessment of event DAS ‐59122‐7 as a single and as a part of stacked events remains valid.