Open AccessScientific Opinion on the substantiation of a health claim related to proanthocyanidins in Urell® and reduction of bacterial colonisation of the urinary tract by inhibition of the adhesion of P‐fimbriated E. coli to uroepithelial cells pursuant to Article 13(5) of Regulation (EC) No 1924/2006
Publication year - 2013
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2013.3326
Subject(s) - colonisation , proanthocyanidin , urinary system , pseudomonas aeruginosa , adhesion , health claims on food labels , food science , microbiology and biotechnology , biology , bacteria , chemistry , medicine , biochemistry , colonization , antioxidant , polyphenol , genetics , organic chemistry
Following an application from Pharmatoka, submitted pursuant to Article 13.5 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to a Urell® product containing cranberry ( Vaccinium macrocarpon ) juice powder standardised for proanthocyanidins (PAC) content and bacterial colonisation of the urinary tract by inhibition of the adhesion of P‐fimbriated E . coli to uroepithelial cells. The food that is the subject of the health claim is PAC in Urell®. The Panel considers that the food constituent, PAC in Urell®, which is the subject of the claim, is sufficiently characterised. The Panel considers that reduction of bacterial colonisation of the urinary tract by inhibition of the adhesion of P‐fimbriated E . coli to uroepithelial cells is a beneficial physiological effect. No human studies from which conclusions could be drawn for the scientific substantiation of the claim were provided by the applicant. The Panel concludes that a cause and effect relationship has not been established between the consumption of proanthocyanidins in Urell® and reduction of bacterial colonisation of the urinary tract by inhibition of the adhesion of P‐fimbriated E. coli to uroepithelial cells.