Open AccessScientific Opinion on Flavouring Group Evaluation 222 (FGE.222): Consideration of genotoxicity data on representatives for alpha, beta‐unsaturated furyl derivatives with the α,β‐unsaturation in the side chain from subgroup 4.6 of FGE.19 by EFSA
Author(s) -
John Christian Larsen,
Karin Nørby,
Vibe Meister Beltoft,
Pia Lund,
MonaLise Binderup,
Henrik Lauritz Frandsen
Publication year - 2012
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2012.2748
Subject(s) - degree of unsaturation , genotoxicity , alpha (finance) , chemistry , beta (programming language) , stereochemistry , organic chemistry , medicine , toxicity , construct validity , nursing , computer science , patient satisfaction , programming language
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of six flavouring substances from subgroup 4.6 of FGE.19 in the Flavouring Group Evaluation 222. The Flavour Industry have provided additional genotoxicity studies for two representative substances, 3‐(2‐furyl)acrylaldehyde [FL‐no: 13.034] and 4‐(2‐furyl)but‐3‐en‐2‐one [FL‐no: 13.044], in FGE.222. Based on these new data the Panel could not rule out a clastogenic and aneugenic potential for the two substances and a in vivo Comet assay was requested for both substances, the one including a micronucleus assay.