Open AccessWithdrawal period for Coxidin® for chickens and turkeys for fattening and re‐examination of the provisional Maximum Residue Limit ‐ Scientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed
Author(s) -
Georges Bories,
Paul Brantom,
Joaquim Brufau de Barberà,
Andrew Chesson,
Bogdan Dębski,
Noël Dierick,
A. Franklin,
Jürgen Gropp,
Ingrid Halle,
Christer Högstrand,
Joop de Knecht,
Ľubomír Leng,
Anne-Katrine Lundebye Haldorsen,
Alberto Mantovani,
Miklós Mézes,
Carlo Nebbia,
W. A. Rambeck,
Guido Rychen,
Pieter Wester
Publication year - 2008
Publication title -
efsa journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.076
H-Index - 97
ISSN - 1831-4732
DOI - 10.2903/j.efsa.2008.731
Subject(s) - food safety , european union , library science , political science , agricultural science , law , business , food science , computer science , biology , economic policy
SUMMARY Following a request from the European Commission, the European Food Safety Authority was asked to deliver a scientific opinion on the proposal for reducing the withdrawal period from three days to one day and the setting of a final maximum residue limit (MRL) for the product Coxidin ® for chickens and turkeys for fattening. No data which would allow proposing a final MRL for monensin in poultry tissues was provided. A number of monensin metabolites (M1, M2, M5, M6) were isolated and tested for their biological activities. All monensin metabolites tested appeared to show lower ionophoric activity than the parent compound. These findings confirm the results of earlier studies. Comparable results on reduced ionophoric activity of metabolites from a related polyether antibiotic support the above findings on monensin. Non-extractable residues in chicken liver and kidney after a one-day withdrawal period amount to more than 50 % of the total residues. About 90 % of total radioactivity was associated with the abdominal fat in chicken for fattening. In milk, about 25 % of the total residues are attributed to fatty acids. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concludes that a considerable part of the non-extractable residues is not drugrelated. The FEEDAP Panel, following a weight of evidence approach, concludes that monensin derived residues of toxicological relevance probably represent, as a conservative estimate, not more than 50 % of the total residues.