Insights into CANDLE Syndrome | Zendy

Katarína Kieselová | Zendy; Felicidade Santiago | Zendy; Martinha Henrique | Zendy

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Insights into CANDLE Syndrome

Author(s) -

Katarína Kieselová,

Felicidade Santiago,

Martinha Henrique

Publication year - 2020

Publication title -

journal of the portuguese society of dermatology and venereology

Language(s) - English

Resource type - Journals

eISSN - 2182-2409

pISSN - 2182-2395

DOI - 10.29021/spdv.78.1.1132

Subject(s) - candle , lipodystrophy , medicine , disease , dermatology , pathology , immunology , chemistry , human immunodeficiency virus (hiv) , antiretroviral therapy , organic chemistry , viral load

Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a recently described chronic autoinflammatory disease, pathophysiologically related to intracellular proteasome/immunoproteasome dysfunction. This review chronicles the recognition of CANDLE syndrome, the developments in the understanding of the pathomechanism, genetic background, and the emerging therapeutic strategies of this condition.

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