Open AccessInsights into CANDLE Syndrome
Author(s) -
Katarína Kieselová,
Felicidade Santiago,
Martinha Henrique
Publication year - 2020
Publication title -
revista da sociedade portuguesa de dermatologia e venereologia
Language(s) - English
Resource type - Journals
eISSN - 2182-2409
pISSN - 2182-2395
DOI - 10.29021/spdv.78.1.1132
Subject(s) - candle , lipodystrophy , medicine , disease , dermatology , pathology , immunology , chemistry , human immunodeficiency virus (hiv) , antiretroviral therapy , organic chemistry , viral load
Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a recently described chronic autoinflammatory disease, pathophysiologically related to intracellular proteasome/immunoproteasome dysfunction. This review chronicles the recognition of CANDLE syndrome, the developments in the understanding of the pathomechanism, genetic background, and the emerging therapeutic strategies of this condition.