Open AccessThe role of β-adrenergic receptors in stress-induced cardiac injury in a rat model of Takotsubo syndrome
Author(s) -
Boris K. Kurbatov,
Е. С. Прокудина
Publication year - 2020
Publication title -
sibirskij medicinskij žurnal
Language(s) - English
Resource type - Journals
ISSN - 2073-8552
DOI - 10.29001/2073-8552-2020-35-2-163-166
Subject(s) - atenolol , antagonist , medicine , supine position , propranolol , adrenergic antagonist , adrenergic receptor , receptor antagonist , pyrophosphate , receptor , endocrinology , adrenergic , chemistry , blood pressure , biochemistry , enzyme
. The pathophysiological mechanisms of cardiac injury in Takotsubo syndrome are currently poorly understood. The role of adrenergic receptor (AR) subtypes in the development of stress-induced myocardial injury (SIMI) remains unclear. Aim. To assess the role of β-ARs in the development of SIMI. Material and Methods . The study was performed using female Wistar rats (n = 84). Rats were subject to 24-hour immobilization in the supine position to simulate SIMI. 99mTc-pyrophosphate radiopharmaceutical was used to determine the degree of cardiac injury. Results . The study showed that β-AR blockade with propranolol reduced the degree of cardiac injury by 38.4%. Selective β1- AR antagonists, atenolol and nebivolol, led to 2.00- and 2.55-fold decreases in 99mTc pyrophosphate accumulation in the heart, respectively. Blockade of β2-ARs by a selective antagonist ICI-118.551 caused an increase in the degree of 99mTc-pyrophosphate accumulation in the heart by 34.6%. A selective β3-AR antagonist L-748337 did not affect 99mTc pyrophosphate accumulation in the heart. Conclusions . The study showed that β1-ARs are involved in the damaging effects of stress on the heart during immobilization stress. β2-AR had a cardioprotective effect in immobilization. β3-AP did not play a significant role in the stress-induced cardiac injury with a single exposure to the stressor.