Open AccessEffects of Vaginal Misoprostol after Intrauterine Insemination IUI
Author(s) -
Zahraa H. Mohan,
Nadia Mudher Al-Hilli,
Mohammad Oda Selman
Publication year - 2020
Publication title -
iraqi journal of embryos and infertility researches
Language(s) - English
Resource type - Journals
eISSN - 2616-6984
pISSN - 2218-0265
DOI - 10.28969/ijeir.v9.i2.r3
Subject(s) - misoprostol , medicine , obstetrics , infertility , gynecology , insemination , pregnancy , pregnancy rate , ectopic pregnancy , intrauterine insemination , abortion , biology , andrology , sperm , genetics
Intrauterine insemination has an important role in the treatment of infertile couples. Usage of vaginal misoprostol therapy at the time of intrauterine insemination has been investigated, and its tolerability and effects on clinical pregnancy rates still questionable. To assess the effectiveness of vaginal misoprostol on some demographic characteristics and hormones level with a success rate of Intrauterine Insemination. the period of collection of patients extended from Sep. 2018 until May 2019. Eighty- one infertile couples who attended Al Nahrain University, High Institute for Diagnostic Infertility and Assisted Reproductive Technologies, and private fertility clinics were enrolled through this study. Divided into two groups, the next group received 100 μg vaginal misoprostol immediately after completion of the IUI procedure, while the control group was subjected to ordinary IUI procedure without adjunctive therapy. The mean of demographic data of body mass index, age, and duration of infertility was statistically insignificant in control, Misoprostol post- intrauterine insemination. The percentage of pregnancy rate in the control group 5.0% and it 19.5% in the Misoprostol post-intrauterine insemination group. Moreover, there are significant differences in pregnancy rates among all study groups. According to this study, there is no significant result of pregnancy occurrences correlated with, female age, male age, and body mass index, duration of infertility or type of infertility, hormone levels. Misoprostol use after intrauterine insemination has a positive impact on pregnancy outcome in the control group 5.0% and it 19.5% in Misoprostol post- intrauterine insemination group. Smaller doses (100 μg) of misoprostol can decrease side effects without affecting the outcome.