Open AccessCorrelation of Pregnancy-Associated Plasma Protein (PAPP-A) in Serum and Follicular Fluid with Oocyte and Embryo Quality in PCOS and non-PCOS Women Undergoing ICSI Cycle
Author(s) -
Zeena Altmimi,
Mufeda Ali Jwad,
Amal Abdulwahid
Publication year - 2021
Publication title -
iraqi journal of embryos and infertility researches
Language(s) - English
Resource type - Journals
eISSN - 2616-6984
pISSN - 2218-0265
DOI - 10.28969/ijeir.v10.i2.r4
Subject(s) - follicular fluid , embryo quality , polycystic ovary , oocyte , pregnancy associated plasma protein a , pregnancy , andrology , hyperinsulinemia , embryo , follicular phase , medicine , endocrinology , biology , insulin resistance , gestation , insulin , first trimester , genetics , microbiology and biotechnology
Pregnancy-Associated Plasma Protein (PAPP-A) is a zinc metalloproteinase in the insulin growth factor system (IGFs) produced by the syncytiotrophoplast region of the placenta. It plays a critical function in the cleavage of IGFBP4. In the ovary IGFs, it regulates follicular and oocyte maturation, and steroidogenesis. While in polycystic ovarian syndrome (PCOS) Hyperinsulinemia and hyperandrogenemia it causes follicular environment changes and early ovulation resulting in lower oocyte and embryo quality in patients and this will decrease the success of pregnancy in women enrolled in the ICSI cycle. The present study aimed to assess the relationship of PAPP-A levels in serum and follicular fluid in women with PCOS and non-PCOS with oocyte and embryo quality in women undergoing ICSI cycle. 45 infertile Iraqi women were enrolled. Women with PCOS had to meet at least two of the three criteria set by the Rotterdam ESHRE/ASRMS criteria, the age of the included women ranged between 20-45 years. In non-PCOS patients, PAPP-A has higher level in serum and follicular fluid but without a statistically significant difference matching with PCOS group. In addition, there was no significant correlation between PAPP-A levels in serum and follicular fluid with oocytes and embryo characteristics. However, PAPP-A levels are higher in serum and follicular fluid in women with positive pregnancy but without significant differences. PAPP-A had no correlation with oocyte and embryo quality.