Open AccessANTIMICROBIAL AND OTHER BIOACTIVE CONSTITUENTS OF Cannabis sativus ROOTS FROM PAKISTAN
Author(s) -
Arshad Javaid,
Iqra Haider Khan,
Malik Fiaz Hussain Ferdosi
Publication year - 2021
Publication title -
pakistan journal of weed science research
Language(s) - English
Resource type - Journals
eISSN - 2225-7942
pISSN - 1815-1094
DOI - 10.28941/pjwsr.v27i3.984
Subject(s) - stigmasterol , phytochemical , chemistry , campesterol , antimicrobial , squalene , traditional medicine , phenol , phenols , sterol , organic chemistry , biochemistry , chromatography , medicine , cholesterol
Hemp (Cannabis sativa L.), a medicinal plant of family Cannabaceae, growing wildly in most of the rainfed areas of Punjab, Pakistan. In this study, phytochemical profile of methanolic extract of root was assessed through GC-MS analysis and various biologically active compounds were identified through literature survey. There were 14 compounds in the root extract. The most abundant compounds were γ-sitosterol (27.08%) and 9,12-octadecadienoic acid (Z,Z)-, methyl ester (24.09%) and hexadecanoic acid, methyl ester (21.81%). Other identified compounds were methyl stearate (5.51%), stigmasterol (5.12%), campesterol (4.19%), phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-methyl-(2.52%), 11-octadecenoic acid, methyl ester (2.10%), squalene (1.89%), β-amyrin (1.88%), eicosanoic acid, methyl ester (0.85%), tetracosanoic acid, methyl ester (0.88%), dronabinol (1.02%) and 2-methoxy-4-vinylphenol (0.96%). Most of the identified compounds possess one or more biological activities viz. antitumor, antifungal, antibacterial, antioxidant, anticancer, anti-inflammatory, antidiabetic, and/or analgesic.