Open AccessSPECTROPHTOTOMETRIC DETERMINATION OF PURE SULFAMETHOXAZOLE IN PHARMACEUTICAL PREPARATIONS BY OXIDATIVE COUPLING REACTION
Author(s) -
Noor M. Ghaib Allah
Publication year - 2021
Publication title -
al-mağallaẗ al-ʿirāqiyyaẗ li-buḥūṯ al-sūq wa-ḥimāyaẗ al-mustahlik/al-mağallaẗ al-ʿirāqiyyaẗ li-buḥūṯ al-sūq wa-ḥimāyaẗ al-mustahlik
Language(s) - English
Resource type - Journals
eISSN - 2523-6180
pISSN - 2071-3894
DOI - 10.28936/jmracpc13.1.2021.(7
Subject(s) - chemistry , chromogenic , potassium iodate , sulfamethoxazole , oxidative coupling of methane , oxidative phosphorylation , chromatography , sulfonic acid , iodine , combinatorial chemistry , nuclear chemistry , organic chemistry , antibiotics , biochemistry , methane
A new, simple, rapid and sensitive spectrophotometric method for the determination of sulfamethoxazole in both pure form and pharmaceutical preparations has been reported.The adapted technique based on utilization 4-aminobenzene sulfonic acid as a new modern chromogenic through an oxidative coupling reaction with sulfamethoxazole and potassium iodate in basic media to form orange soluble dye product with absorption maxima at 490 nm. Subject to Beer's law in the range 2–32μg mL-1. The values of molarabsorption coefficient (ε) and correlation coefficient were found to be 9.118 × 103 and0.9999 respectively whereas the Sandels index was 0. 02778 µg.cm-2