Open AccessSYNTHESIS, CHARACTERIZATION, AND STUDY THE BIOLOGICAL ACTIVITY OF SOME SCHIFF'S BASES, AND 1,3 - OXAZEPINE COMPOUNDS DERIVED FROM SULFAMETHOXAZOLE DRUG
Author(s) -
Enaam Fadhil Mousa,
Ibtisam K. Jassim
Publication year - 2021
Publication title -
al-mağallaẗ al-ʿirāqiyyaẗ li-buḥūṯ al-sūq wa-ḥimāyaẗ al-mustahlik/al-mağallaẗ al-ʿirāqiyyaẗ li-buḥūṯ al-sūq wa-ḥimāyaẗ al-mustahlik
Language(s) - English
Resource type - Journals
eISSN - 2523-6180
pISSN - 2071-3894
DOI - 10.28936/jmracpc13.1.2021.(5
Subject(s) - schiff base , chemistry , staphylococcus aureus , antibacterial activity , agar diffusion test , sulfamethoxazole , succinic anhydride , escherichia coli , organic chemistry , antifungal , combinatorial chemistry , nuclear chemistry , microbiology and biotechnology , stereochemistry , antibiotics , bacteria , biochemistry , biology , genetics , gene
This study including synthesis of some new Schiff bases compounds [1‐6] from the reaction of Sulfamethoxazole drug with some aromatic aldehydes in classical Schiff base method then treatment Schiff bases with succinic anhydride to get oxazepines rings [7-11]These derivatives were characterized by melting point, FT‐IR, 1H NMR and mass spectra. Some of synthesized compounds were evaluated in vitro for their antibacterial activities against three kinds of pathogenic strains Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa by agar diffusion disk method, and against the fungal species (Candida). The results showed that some of these derivatives have good antibacterial activities compared to biological activity of parent drug.