Open AccessELECTROCHEMICAL PREPARATION OF A MOLECULAR IMPRINTED POLYMER ELECTRODE FOR ESTEMATION OF ASPIRIN USING TWO DIFFERENT FUNCTIONAL MONOMERS.
Author(s) -
Aseel S. Mansoor
Publication year - 2021
Publication title -
al-mağallaẗ al-ʿirāqiyyaẗ li-buḥūṯ al-sūq wa-ḥimāyaẗ al-mustahlik/al-mağallaẗ al-ʿirāqiyyaẗ li-buḥūṯ al-sūq wa-ḥimāyaẗ al-mustahlik
Language(s) - English
Resource type - Journals
eISSN - 2523-6180
pISSN - 2071-3894
DOI - 10.28936/jmracpc13.1.2021.(2
Subject(s) - molecularly imprinted polymer , electrode , detection limit , polymerization , materials science , differential pulse voltammetry , electrochemistry , cyclic voltammetry , monomer , chemistry , polymer , analytical chemistry (journal) , nuclear chemistry , chemical engineering , chromatography , organic chemistry , composite material , selectivity , catalysis , engineering
For aspirin estimated, a molecularly imprinted polymer MIP-ASP electrodes were generated by electro-polymerization process, the electrodes were prepared by combining the template (aspirin) with (vinyl acetate (VA), 1-vinylimidizole (VIZ) as a functional monomer and N, N-methylene bisacrylamide (MBAA) as crosslinkers using benzoyl peroxide (BPO) as an initiator. The efficiency of the membrane electrodes was analyzed by differential pulse voltammetry (DPV). Four electrodes were synthesized using two different plasticizers, di-butyl sebacate (DBS), di-octyl phthalate (DOP) in PVC matrix. Scanning electron microscopy (SEM) was used to describe the generated MIP, studying the electrodes properties, the slope, detection limit, and life time and linearity range. The effect of PH and interferes on the efficiency of the MIP electrode was investigated. The study has shown that the molecularly imprinted electrodes have high sensitivity and responsiveness to aspirin. The DPV value was linearly dependence on the aspirin concentration and a linear curve was obtained within the range of (1×10−1-5×10-4) M of aspirin with correlation coefficients are about (0.9974, 0.9966, 0.9938 and 0.9961) with slops value of (-21.41, -17.67, -17.47 and -18.67) and the detection limit for all electrodes ranging from (7.5×10-5-1×10-4) M. The molecularly imprinted electrode exhibited a good response with highly reproducible and no effect on interferes frequently available in pharmaceutical formulations. The approach employed is easy and fast. Also ASP membranes get a limited time of response, excellent mechanical stability, removable and are easy to construct.