Open AccessAdjunctive hyperbaric oxygen treatment for necrotising soft-tissue infections: A systematic review and meta-analysis
Author(s) -
Morten Hedetoft,
Michael H Bennett,
Ole Hyldegaard
Publication year - 2021
Publication title -
diving and hyperbaric medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.389
H-Index - 20
eISSN - 2209-1491
pISSN - 1833-3516
DOI - 10.28920/dhm51.1.34-43
Subject(s) - medicine , meta analysis , odds ratio , amputation , medline , adjunctive treatment , surgery , intensive care medicine , political science , law
Surgical intervention, broad-spectrum antibiotics and intensive care support are the standard of care in the treatment of necrotising soft-tissue infections (NSTI). Hyperbaric oxygen treatment (HBOT) may be a useful adjunctive treatment and has been used for almost 60 years, but its efficacy remains unknown and has not been systematically appraised. The aim was to systematically review and synthesise the highest level of clinical evidence available to support or refute the use of HBOT in the treatment of NSTI.