Open AccessCalculated risk of pulmonary and central nervous system oxygen toxicity: a toxicity index derived from the power equation
Author(s) -
Ran Arieli
Publication year - 2019
Publication title -
diving and hyperbaric medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.389
H-Index - 20
eISSN - 2209-1491
pISSN - 1833-3516
DOI - 10.28920/dhm49.3.154-160
Subject(s) - oxygen toxicity , toxicity , oxygen , pulmonary toxicity , acute toxicity , anesthesia , chemistry , medicine , organic chemistry
The risk of oxygen toxicity has become a prominent issue due to the increasingly widespread administration of hyperbaric oxygen (HBO) therapy, as well as the expansion of diving techniques to include oxygen-enriched gas mixtures and technical diving. However, current methods used to calculate the cumulative risk of oxygen toxicity during an HBO exposure i.e., the unit pulmonary toxic dose concept, and the safe boundaries for central nervous system oxygen toxicity (CNS-OT), are based on a simple linear relationship with an inspired partial pressure of oxygen (PO 2 ) and are not supported by recent data.