Emergence and dissemination of multidrug resistant clones of Pseudomonas aeruginosa producing VIM-2 metallo-beta-lactamase in Belgium

Emergence of carbapenem-hydrolysing metallo-beta-lactamase (MBL) in Pseudomonas aeruginosa has been described worldwide. Infection with MBL-producing strains represents a therapeutic problem due to their resistance to all beta-lactams except monobactams. Several types of MBL enzymes have been identified in P. aeruginosa among which the VIM-type enzymes appear as the most prevalent in Europe with more than 12 allelic variants.