Open AccessPathology and biochemistry of prion disease varies with genotype in transgenic mice
Author(s) -
Kate Soldan
Publication year - 2004
Language(s) - English
Resource type - Journals
ISSN - 9999-1233
DOI - 10.2807/esw.08.47.02587-en
Subject(s) - genetically modified mouse , transgene , genotype , disease , gene , methionine , biology , human pathology , prion protein , pathology , genetics , virology , medicine , amino acid
The development of variant Creutzfeldt-Jakob disease in transgenic mice expressing the human PrP gene only occurred in those mice that were methionine homozygotes at codon 129 of that gene, according to a recently published study