Open AccessExperiments provide compelling evidence of protein-only prion infectivity, and that prion strain differences must be structural
Publication year - 2004
Language(s) - English
Resource type - Journals
ISSN - 9999-1233
DOI - 10.2807/esw.08.15.02439-en
Subject(s) - infectivity , prion protein , nucleic acid , strain (injury) , virology , biology , fungal prion , infectious agent , prion proteins , genetics , virus , phenotype , gene , medicine , disease , pathology , anatomy
Results of experiments by two prion research groups support the view that prions are protein-based, infectious entities not made up of transmissible nucleic acids. In these experiments, infectivity with purified prion protein was demonstrated