Open AccessRobustness of measles immunity in parturient women in Gipuzkoa, Basque Country, Spain, in the post-vaccination era
Author(s) -
Gustavo Cilla,
E. Serrano-Bengoechea,
Diego Vicente,
Milagros Montes,
E Pérez-Trallero
Publication year - 2007
Publication title -
euro surveillance/eurosurveillance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.766
H-Index - 104
eISSN - 1560-7917
pISSN - 1025-496X
DOI - 10.2807/esm.12.09.00732-en
Subject(s) - measles , medicine , vaccination , immunity , measles vaccine , passive immunity , immunization , immunology , pediatrics , herd immunity , measles virus , antibody , obstetrics , immune system
The infants of mothers with vaccine-induced immunity lose passive acquired measles antibodies earlier than infants of naturally infected mothers. This study included two cohorts of parturient women: one composed of women who gave birth in 1990 (end of the epidemic period), and another comprising women who gave birth in 2006 (after eight years without virus circulation). Immunoglobulin G (IgG) antibodies against measles (IgG-AM) were investigated by enzyme immunoassay in stored serum samples (-40°C). Measles-IgG titres of >400 mIU/mL were found in all 185 parturient women who gave birth in 1990, all with natural immunity. Of 185 women who gave birth in 2006, most of whom had vaccine-induced protection, measles-IgG were undetectable in 4.9% (