Open AccessTumor stroma fosters neovascularization by recuitment of progenitor cells into the tumor bed
Author(s) -
Ganss Ruth
Publication year - 2006
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.2755/jcmm010.004.01
Subject(s) - stromal cell , neovascularization , stroma , progenitor cell , angiogenesis , biology , cancer research , carcinogenesis , tumor progression , tumor cells , tumor microenvironment , pathology , stem cell , microbiology and biotechnology , cancer , immunology , medicine , immunohistochemistry , genetics
The tumor stroma is an active player during carcinogenesis and contains a variety of cell types such as vascular cells, fibroblasts and inflammatory cells which directly or indirectly foster neovascularization. During tumor progression stromal cells, in particular the neovasculature, acquire new characteristics distinct from their normal counterparts and display a high degree of plasticity to meet the tumor's demands. The local environment may, to some extent, shape pre‐existing, tumor‐resident stromal cells. However, there is accumulating evidence that new endothelial and other stromal cells are actively recruited into tumors, and that this recruitment is essential for a unique and tumor‐specific proangiogenic environment.