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Antimicrobial associated diarrhoea in the horse. Part 1: Overview, pathogenesis and risk factors
Author(s) -
McGorum B. C.,
Pirie R. S.
Publication year - 2009
Publication title -
equine veterinary education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 31
eISSN - 2042-3292
pISSN - 0957-7734
DOI - 10.2746/095777309x476871
Subject(s) - medicine , antimicrobial , diarrhea , incidence (geometry) , enterocolitis , horse , limiting , adverse effect , intensive care medicine , microbiology and biotechnology , mechanical engineering , paleontology , physics , optics , biology , engineering
Summary Antimicrobial associated diarrhoea (AAD) is the most commonly recognised adverse effect of antimicrobial treatment in horses, although its incidence is probably low given the frequency of antimicrobial administration. Clinical signs vary from transient self‐limiting diarrhoea to rapidly fatal toxic enterocolitis. AAD prolongs the duration of hospitalisation, increases diagnostic and therapeutic costs, and was associated with a lower case survival rate than other types of acute diarrhoea in one study. Virtually all antimicrobials have been implicated in AAD, but some pose a greater risk than others.