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The composition of the inflammatory infiltrate in three cases of polyneuritis equi
Author(s) -
GALEN G.,
CASSART D.,
SANDERSEN C.,
DELGUSTE C.,
NOLLET H.,
AMORY H.,
DUCATELLE R.
Publication year - 2008
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.2746/042516408x276933
Subject(s) - myelin , cytotoxic t cell , horse , immune system , immunology , medicine , lymphocyte , antibody , lymphocyte subsets , pathology , biology , t cell , central nervous system , in vitro , paleontology , biochemistry
Summary Polyneuritis equi (PNE) is a rare neurological disease in the horse. Because of the suspicion in PNE of a T‐lymphocyte mediated immune response against the myelin, the objective of this study was to determine the composition of the inflammatory infiltrate in the involved nerves of 3 horses with PNE, studied retrospectively. T‐lymphocytes were demonstrated in the lesions, which suggests a T‐lymphocyte mediated immune response against myelin. In addition, the presence of B‐lymphocytes indicated a local production of antibodies. More research, involving a prospective study, is needed to determine whether the T‐lymphocytes are cytotoxic or T‐helper lymphocytes.