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Effect of a constant rate infusion of lidocaine on the quality of recovery from sevoflurane or isoflurane general anaesthesia in horses
Author(s) -
VALVERDE A.,
GUNKEL C.,
DOHERTY T. J.,
GIGUÈRE S.,
POLLAK A. S.
Publication year - 2005
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.2746/042516405775314772
Subject(s) - lidocaine , anesthesia , medicine , isoflurane , sevoflurane , bolus (digestion) , saline , surgery
Summary Reasons for performing study : Lidocaine constant rate infusions (CRIs) are common as an intraoperative adjunct to general anaesthesia, but their influence on quality of recovery has not been thoroughly determined. Objectives : To determine the effects of an intraoperative i.v. CRI of lidocaine on the quality of recovery from isoflurane or sevoflurane anaesthesia in horses undergoing various surgical procedures, using a modified recovery score system. Hypothesis : The administration of intraoperative lidocaine CRI decreases the quality of recovery in horses. Methods : Lidocaine (2 mg/kg bwt bolus followed by 50 μg/kg bwt/min) or saline was administered for the duration of surgery or until 30 mins before the end of surgery under isoflurane (n = 27) and sevoflurane (n = 27). Results : Horses receiving lidocaine until the end of surgery had a significantly higher degree of ataxia and a tendency towards significance for a lower quality of recovery. There was no correlation between lidocaine plasma concentrations at recovery and the quality of recovery. Conclusions : Intraoperative CRI of lidocaine affects the degree of ataxia and may decrease the quality of recovery. Potential relevance : Discontinuing lidocaine CRI 30 mins before the end of surgery is recommended to reduce ataxia during the recovery period.