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Concentration of methylprednisolone in the centrodistal joint after administration of methylprednisolone acetate in the tarsometatarsal joint
Author(s) -
SERENA A.,
SCHUMACHER J.,
SCHRAMME M. C.,
DEGRAVES F.,
BELL E.,
RAVIS W.
Publication year - 2005
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.2746/0425164054223778
Subject(s) - methylprednisolone , osteoarthritis , methylprednisolone acetate , hock , medicine , saline , joint pain , horse , lameness , joint (building) , anesthesia , surgery , pathology , anatomy , architectural engineering , paleontology , alternative medicine , biology , engineering
Summary Reasons for performing study : The centrodistal (CD) and tarsometatarsal (TMT) joints are often injected individually with a corticosteroid to resolve lameness caused by osteoarthritis (OA). There are no data available regarding diffusion of methylprednisolone (MP) from the TMT joint to the CD joint. Hypothesis : A therapeutic concentration of MP diffuses into the CD joint after methylprednisolone acetate (MPA) is administered into the TMT joint. Objective : To measure the concentration of MP in the CD joint after MPA was administered into the TMT joint. Methods : MPA was administered into a TMT joint of 16 horses. At different times, the ipsilateral CD joint of these horses was injected with a small amount of saline and recovered saline was measured for concentration of MP using high performance liquid chromatography. Results : Six hours after administration of MPA into the TMT joint, a therapeutic concentration of MP was found in all 10 CD joints sampled at this time. Conclusions : Horses with pain arising from the distal 2 joints of the hock can be treated by administering MPA into the TMT joint alone. Potential relevance : Administering MPA into the TMT joint only, to treat OA of the distal 2 hock joints, reduces the difficulties and risks associated with centesis of the CD joint.