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Deslorelin acetate (Ovuplant) therapy in cycling mares: effect of implant removal on FSH secretion and ovarian function
Author(s) -
FARQUHAR V. J.,
McCUE P. M.,
CARNEVALE E. M.,
NETT T. M.,
SQUIRES E. L.
Publication year - 2002
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.2746/042516402776249227
Subject(s) - ovulation , follicular phase , implant , medicine , endocrinology , estrous cycle , hormone , surgery
Summary Following induction of ovulation with deslorelin acetate (Ovuplant) 1 , gonadotrophin concentrations are reduced in the subsequent cycle, leading to increased interovulatory intervals in some mares. This study determined whether implant removal after 2 days prevented the decrease in gonadotrophin concentrations and follicular growth during the ensuing cycle. Twenty‐four mares were randomised equally into 3 groups. Group 1 ovulated spontaneously, Groups 2 and 3 received the deslorelin implant to induce ovulation. Two days after treatment, the implant was removed from Group 3. On Day 10 postovulation, FSH was lower (P = 0.009) in Group 2 , but not different between Groups 1 and 3. Follicular diameter on Day 14 was less (P<0.05) in Group 2 (19.0 ± 2.1 mm) than in Groups 1 and 3 (36.6 ± 2.5 and 30.5 ± 2.0 mm, respectively). Interovulatory interval was longer (P<0.05) for Group 2 (25.8 ± 2.9 days) compared to Groups 1 and 3 (18.5 ± 0.7 and 19.4 ± 0.3 days, respectively). Removal of the deslorelin implant eliminated the decreased FSH secretion and the increased interovulatory interval associated with implant administration. Therefore, it is recommended that the implant be removed after ovulation is detected to prevent the occurrence of a prolonged interovulatory interval.