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Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves‐affected horses
Author(s) -
KIRSCHVINK N.,
SMITH N.,
FIÉVEZ L.,
BOUGNET V.,
ART T.,
DEGAND G.,
MARLIN D.,
ROBERTS C.,
GÉNICOT B.,
LINDSEY P.,
LEKEUX P.
Publication year - 2002
Publication title -
equine veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.82
H-Index - 87
eISSN - 2042-3306
pISSN - 0425-1644
DOI - 10.2746/042516402776180223
Subject(s) - uric acid , medicine , glutathione , systemic inflammation , horse , oxidative stress , bronchoalveolar lavage , antioxidant , gastroenterology , airway resistance , venous blood , inflammation , pulmonary function testing , endocrinology , immunology , respiratory system , lung , chemistry , biochemistry , enzyme , biology , paleontology
Summary In heaves‐affected horses the relation between oxidant status, airway inflammation (AI) and pulmonary function (PF) is unknown. The oxidant status of blood and pulmonary epithelial lining fluid (PELF) of healthy (H, n = 6) and heaves‐affected horses in clinical remission (REM, n = 6) and in crisis (CR, n = 7) was assessed at rest, during and afterstandardised exercise test by measurement of reduced and oxidised glutathione, glutathione redox ratio [GRR%]; uric acid and 8‐epi‐PGF 2α . Oxidant status was related to PF parameters (mechanics of breathing and arterial blood gas tension) and AI parameters (bronchoalveolar lavage [BAL] neutrophil% and AI score). Haemolysate glutathione was significantly different between groups and was correlated with PF and AI parameters; GRR in PELF was increased during CR and was correlated with PF and AI parameters. Exercise induced an increase of plasma uric acid that was significantly higherboth in REM and CR. PELF 8‐epi‐PGF 2α was significantly increased in CR and correlated with PF and AI parameters. These results suggest that oxidative stress occurring in heaves is correlated with PF and AI and may be locally assessed by PELFglutathione status, uric acid and 8‐epi‐PGF 2α . Systemic repercussions are reflected by assay of GSH in resting horses and by uric acid in exercising horses.