Open AccessHubungan antara Infeksi Cacing dan Alergi
Author(s) -
Yolazenia Yolazenia,
Taniawati Supali,
Heri Wibowo
Publication year - 2017
Publication title -
jurnal ilmu kedokteran /jurnal ilmu kedokteran
Language(s) - English
Resource type - Journals
eISSN - 2715-4467
pISSN - 1978-662X
DOI - 10.26891/jik.v4i2.2010.71-78
Subject(s) - hygiene hypothesis , helminthiasis , immunoglobulin e , immunology , eosinophilia , allergy , medicine , antibody
Many researches showing the evidence of a reverse relation between helminthiasis and allergic diseases in tropicaldeveloping countries, supported by hygiene hypothesis. There is relationship between the inflammation caused byallergic and helminthiasis. Both, allergic and helminthiasis, show the increase of IgE level, eosinophilia, mastocytosis,and release of IL-4, IL-5 and IL-13 cytokines by Th2. Several mechanisms explaining the decrease of allergicmanifestation in people with helminthiasis are polyclonal IgE blocking, suppression of anti-inflammatory cytokines(IL-10 and TGF-â), and IgG4 blocking antibody.