Open AccessScreening of coformers for quercetin cocrystals through mechanochemical methods
Author(s) -
Fayene Zeferino Ribeiro de Souza,
Amanda Cosmo de Almeida,
Patrícia Osório Ferreira,
Richard Perosa Fernandes,
Flávio Júnior Caires
Publication year - 2022
Publication title -
eclética química
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.177
H-Index - 19
eISSN - 1678-4618
pISSN - 0100-4670
DOI - 10.26850/1678-4618eqj.v47.1.2022.p64-75
Subject(s) - isonicotinamide , cocrystal , synthon , fourier transform infrared spectroscopy , chemistry , powder diffraction , solubility , infrared spectroscopy , thermal analysis , materials science , organic chemistry , combinatorial chemistry , nuclear chemistry , chemical engineering , crystallography , molecule , thermal , hydrogen bond , physics , meteorology , engineering
Quercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects. Although QUE is well-known for its benefits, its efficacy is limited due to low solubility. Thus, cocrystallization acts as an interesting approach to improve the solubilityamong other propertiesof this compound. In this work, cocrystallization screening was applied through neat grinding (NG) and liquid-assisted grinding (LAG), in which QUE and four cocrystal formers (benzamide,picolinamide, isonicotinamide, and pyrazinoic acid) were tested. The precursors and QUE-coformer systems were characterized using thermoanalytical techniques (TG-DTA), X-ray powder diffraction (XRPD), and Fourier transform infrared (FTIR) spectroscopy. The results showed the formation of QUE cocrystals with picolinamide and isonicotinamide coformers in a 1:1 stoichiometric ratio. Furthermore, although coformers are isomers, spectroscopic and thermal data suggest that the supramolecular synthons involved in cocrystallization are different.