Open AccessRed cell alloimmunization in sickle-cell anaemia patients
Author(s) -
Layla Bashawri
Publication year - 2007
Publication title -
eastern mediterranean health journal/eastern mediterranean health journal
Language(s) - Slovenian
Resource type - Journals
SCImago Journal Rank - 0.442
H-Index - 47
eISSN - 1687-1634
pISSN - 1020-3397
DOI - 10.26719/2007.13.5.1181
Subject(s) - medicine , red cell , antibody , medical record , isoantibodies , retrospective cohort study , pediatrics , antigen , coombs test , immunology
This study in King Fahd Hospital of the University, Saudi Arabia, assessed the frequency of alloimmunization to red cell antigens in sickle-cell anaemia patients over 1996-2004 in order to evaluate the risk of alloimmunization and identify the most common alloantibodies. A retrospective analysis of the transfusion history and medical records of 350 patients aged 2 to 75 years who had received at least 1 transfusion found that 48 patients had developed alloantibodies (13.7%). The most common alloantibodies detected were: anti-E alone (18.8%), nonspecific (12.5%), inconclusive (12.5%), anti-K (10.4%) and anti-c 3 (6.3%). Some patients had 1 alloantibody, while others more than 1 and even multiple antibodies. Nine patients had a persistent positive direct antiglobulin test.