Open AccessSerum levels of astroglial S100-beta and neuron-specific enolase in hepatic encephalopathy patients
Author(s) -
Abdullah S. Al Saleh,
Laith Abul-Ellah Kamel,
A. Ghali,
Abdel-Rahman Ismail,
Hisham El Khayat
Publication year - 2007
Publication title -
eastern mediterranean health journal/eastern mediterranean health journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.442
H-Index - 47
eISSN - 1687-1634
pISSN - 1020-3397
DOI - 10.26719/2007.13.5.1114
Subject(s) - enolase , hepatic encephalopathy , cirrhosis , medicine , neuron , gastroenterology , pathology , immunology , immunohistochemistry , psychiatry
To find a reliable, noninvasive method for the diagnosis of cognitive impairment in patients with hepatic cirrhosis we measured serum levels of astroglial S100beta and neuron-specific enolase in cirrhotic patients with and without hepatic encephalopathy (HE). S100beta levels showed a significant increase in groups with HE stage 1 and 2 compared to both control and cirrhosis patients. However serum neuron-specific enolase levels were not significantly different between the studied groups. S100beta levels had a specificity of 91.3% and sensitivity of 51.7% for detection of HE from cirrhosis. Serum S100beta may be a useful surrogate marker for the diagnosis of mild cognitive impairment in cirrhotic patients before they progress to more advanced stages of HE.