Open AccessAntiphospholipid syndrome and retinal vein occlusion in adults
Author(s) -
R M Maaroufi,
Rawaa Hamdi,
N Jmili,
M Ghorbal,
Bel Hadj F Hamida,
Touhami Mahjoub
Publication year - 2004
Publication title -
eastern mediterranean health journal/eastern mediterranean health journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.442
H-Index - 47
eISSN - 1687-1634
pISSN - 1020-3397
DOI - 10.26719/2004.10.4-5.627
Subject(s) - medicine , central retinal vein , retinal vein , antiphospholipid syndrome , fluorescein angiography , anticoagulant , retinal , ophthalmology , occlusion , lupus anticoagulant , cardiology , thrombosis
Antiphospholipid antibodies may play and important role in the pathogenesis of retinal vascular occlusions; investigated the prevalence among 33 patients with retinal vein and artery occlusions and 80 controls. Prevalence was 33% and 5% respectively. Ophthalmic examination and fluorescein angiography showed that occlusions were due to ischaemic events. The 11 patients were diagnosed with antiphospholipid syndrome:9 patients were treated successfully with laser photocoagulation and anticoagulant and anti-aggregant therapy. Two patients with antiphospholipid antibodies associated with resistance to activated protein C had unfavourable outcomes. Our results suggest a correlation between antiphospholipid syndrome and retinal vein occlusions; we recommend a systematic search for antiphospholipid antibodies in occlusions of unexplained origin and laser photocoagulation treatment and long-term oral anticoagulant and anti-aggregant therapy