Open AccessQuinine for chloroquine-resistant falciparum malaria in pregnant Sudanese women in the first trimester
Author(s) -
Ishaq Adam,
Idris Hm,
Elbashir Mi
Publication year - 2004
Publication title -
eastern mediterranean health journal/eastern mediterranean health journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.442
H-Index - 47
eISSN - 1687-1634
pISSN - 1020-3397
DOI - 10.26719/2004.10.4-5.560
Subject(s) - quinine , medicine , malaria , pregnancy , chloroquine , obstetrics , plasmodium falciparum , gestational age , abortion , prospective cohort study , gestation , pediatrics , surgery , genetics , immunology , biology
A prospective clinical study in eastern Sudan described the efficacy and toxicity of quinine in early pregnancy in mothers with chloroquine-resistant falciparum malaria. Twenty-six pregnant Sudanese women in their first trimester [mean gestational age 8.5 weeks] were given quinine 10 mg/kg 3 times per day for 7 days and followed up every 2 weeks until delivery. One patient aborted [3.8%] and 2 patients [7.7%] experienced threatened abortion but delivered term babies. Recrudescence or re-infection was observed on day 21 in 1 patient. One baby died aged 6 months. There were no detectable congenital malformations, no auditory or visual defects or any other neurological deficits in the remaining infants at birth or 1 year later. Quinine may be safe in the first trimester of pregnancy